Cambridge was established in 2000. A men's team first entered league competition in 2004/05, while a women's team has been playing competitively for five years and secured promotion to Super-8 in 2015/16. The men's 1st team is a mainstay of the top English leagues, and in 2014/2015 participated in the EHF Challenge Cup, playing against the Romanian side Szekelyudvarhely.
Cambridge is a sociable club and welcomes players of all abilities. It currently has two competitive men's teams (in the Super-8 and the RDL) and one women's team (in the Super-8), as well as a growing junior section. The Cambridge University Handball Club is Cambridge's Satellite Club and they are trying to grow handball regionally by establishing other junior Satellite Clubs with schools.